Article
Risk of nontyphoidal Salmonella bacteraemia in African children is modified by STAT4.
Nature communications - 9 Mar 2018
Gilchrist James J, Rautanen Anna, Fairfax Benjamin P, Mills Tara C, Naranbhai Vivek, Trochet Holly, Pirinen Matti, Muthumbi Esther, Mwarumba Salim, Njuguna Patricia, Mturi Neema, Msefula Chisomo L, Gondwe Esther N, MacLennan Jenny M, Chapman Stephen J, Molyneux Malcolm E, Knight Julian C, Spencer Chris C A, Williams Thomas N, MacLennan Calman A, Scott J Anthony G, Hill Adrian V S
Abstract excerpt
Nontyphoidal Salmonella (NTS) is a major cause of bacteraemia in Africa. The disease typically affects HIV-infected individuals and young children, causing substantial morbidity and mortality. Here we present a genome-wide association study (180 cases, 2677 controls) and replication analysis of NTS bacteraemia in Kenyan and Malawian children. We identify a locus in STAT4, rs13390936, associated with NTS...
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