Article

IFN-λ4 Genetic Variants Influence Clinical Malaria Episodes in A Cohort of Kenyan Children

2020-09-18

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Interferon (IFN)- λ4, a type III IFN, production is controlled by a dinucleotide frameshift variant (rs368234815-dG/TT) within the first exon of the <italic>IFNL4</italic> gene. Carriers of the <italic>IFNL4</italic>-dG allele but not the <italic>IFNL4</italic>-TT allele are able to produce the IFN-λ4 protein. Patients with hepatitis C virus that do not produce...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5386817e-7fdc-5e47-9457-a171f201af6e
DOI: 10.21203/rs.3.rs-74934/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

IFN-λ4 Genetic Variants Influence Clinical Malaria Episodes in A Cohort of Kenyan ChildrenDOI 10.21203/rs.3.rs-74934/v1Read

IFN-λ4 genetic variants influence clinical malaria episodes in a cohort of Kenyan children.Semantic proximity Read

IFN-λ4 is associated with increased risk and earlier occurrence of gastrointestinal, respiratory and malarial infections in Malian childrenSemantic proximity Read

IFN-λ4 is associated with increased risk and earlier occurrence of several common infections in African children.Semantic proximity Read

Type I Interferon Receptor Variants in Gene Regulatory Regions are Associated with Susceptibility to Cerebral Malaria in Malawi.Semantic proximity Read

Diversity of KIR genes and their HLA-C ligands in Ugandan populations with historically varied malaria transmission intensitySemantic proximity Read

Reduced interferon (IFN)-α conditioned by IFNA2 (-173) and IFNA8 (-884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality.Semantic proximity Read

IFNL4 Genotypes and Risk of Childhood Burkitt Lymphoma in East Africa.Semantic proximity Read

The effect of human genetic factors on childhood malaria in Asembo, Western KenyaSemantic proximity Read

A rare non-synonymous c.102C>G SNP in the IFNB1 gene might be a risk factor for cerebral malaria in Indian populations.Semantic proximity Read

Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in the Gambia.Semantic proximity Read

Integrated OMICS platforms identify LAIR1 genetic variants as novel predictors of cross-sectional and longitudinal susceptibility to severe malaria and all-cause mortality in Kenyan childrenSemantic proximity Read

Effect of red blood cell variants on childhood malaria in Mali: a prospective cohort study.Semantic proximity Read