IFN-λ4 genetic variants influence clinical malaria episodes in a cohort of Kenyan children.

doi:10.1186/s12936-021-03689-z

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Article

IFN-λ4 genetic variants influence clinical malaria episodes in a cohort of Kenyan children.

Malaria journal - 21 Apr 2021

Samayoa-Reyes Gabriela, Jackson Conner, Ogolla Sidney, Sabourin Katherine, Obajemu Adeola, Dent Arlene E, Prokunina-Olsson Ludmilla, Rochford Rosemary

Abstract excerpt

BACKGROUND: Interferon (IFN)- λ4, a type III IFN, production is controlled by a dinucleotide frameshift variant (rs368234815-dG/TT) within the first exon of the IFNL4 gene. Carriers of the IFNL4-dG allele but not the IFNL4-TT allele are able to produce the IFN-λ4 protein. Patients with hepatitis C virus that do not produce the IFN-λ4 protein have higher rates of viral clearance suggesting a potential inhibitory...

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PMID: 33882912
DOI: 10.1186/s12936-021-03689-z
PMCID: PMC8058600

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