Comparative analysis of rs12979860 SNP of the IFNL3 gene in children with hepatitis C and ethnic matched controls using 1000 Genomes Project data.

doi:10.1371/journal.pone.0085899

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Article

Comparative analysis of rs12979860 SNP of the IFNL3 gene in children with hepatitis C and ethnic matched controls using 1000 Genomes Project data.

PloS one - 1 Jan 2014

Indolfi Giuseppe, Mangone Giusi, Bartolini Elisa, Nebbia Gabriella, Calvo Pier Luigi, Moriondo Maria, Tovo Pier-Angelo, de Martino Maurizio, Azzari Chiara, Resti Massimo

Abstract excerpt

The rs12979860 single nucleotide polymorphism located on chromosome 19q13.13 near the interferon L3 gene (formerly and commonly known as interleukin 28B gene) has been associated in adults with both spontaneous and treatment induced clearance of hepatitis C virus. Although the exact mechanism of these associations remains unclear, it suggests that variation in genes involved in the immune response against the...

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PMID: 24465773
DOI: 10.1371/journal.pone.0085899
PMCID: PMC3895017

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IFNL3

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