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Article

Human-specific gain of function in a developmental enhancer.

Science (New York, N.Y.) - 5 Sept 2008

Prabhakar Shyam, Visel Axel, Akiyama Jennifer A, Shoukry Malak, Lewis Keith D, Holt Amy, Plajzer-Frick Ingrid, Morrison Harris, Fitzpatrick David R, Afzal Veena, Pennacchio Len A, Rubin Edward M, Noonan James P

Abstract excerpt

Changes in gene regulation are thought to have contributed to the evolution of human development. However, in vivo evidence for uniquely human developmental regulatory function has remained elusive. In transgenic mice, a conserved noncoding sequence (HACNS1) that evolved extremely rapidly in huma...

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Identifiers

PMID: 18772437
DOI: 10.1126/science.1159974
PMCID: PMC2658639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18772437-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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