Article
Central human B cell tolerance manifests with a distinctive cell phenotype and is enforced via CXCR4 signaling in hu-mice.
Proceedings of the National Academy of Sciences of the United States of America - 20 Apr 2021
Alves da Costa Thiago, Peterson Jacob N, Lang Julie, Shulman Jeremy, Liang Xiayuan, Freed Brian M, Boackle Susan A, Lauzurica Pilar, Torres Raul M, Pelanda Roberta
Abstract excerpt
Central B cell tolerance, the process restricting the development of many newly generated autoreactive B cells, has been intensely investigated in mouse cells while studies in humans have been hampered by the inability to phenotypically distinguish autoreactive and nonautoreactive immature B cell clones and the difficulty in accessing fresh human bone marrow samples. Using a human immune system mouse model in...
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