Article
A Transcription Start Site Map in Human Pancreatic Islets Reveals Functional Regulatory Signatures.
Diabetes - 1 Jul 2021
Varshney Arushi, Kyono Yasuhiro, Elangovan Venkateswaran Ramamoorthi, Wang Collin, Erdos Michael R, Narisu Narisu, Albanus Ricardo D'Oliveira, Orchard Peter, Stitzel Michael L, Collins Francis S, Kitzman Jacob O, Parker Stephen C J
Abstract excerpt
Identifying the tissue-specific molecular signatures of active regulatory elements is critical to understand gene regulatory mechanisms. Here, we identify transcription start sites (TSS) using cap analysis of gene expression (CAGE) across 57 human pancreatic islet samples. We identify 9,954 reproducible CAGE tag clusters (TCs), ∼20% of which are islet specific and occur mostly distal to known gene TSS. We...
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