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Article

Compensation for the absence of the catalytically active half of DNA polymerase ε in yeast by positively selected mutations in CDC28.

Genetics - 24 Jun 2021

Stepchenkova Elena I, Zhuk Anna S, Cui Jian, Tarakhovskaya Elena R, Barbari Stephanie R, Shcherbakova Polina V, Polev Dmitrii E, Fedorov Roman, Poliakov Eugenia, Rogozin Igor B, Lada Artem G, Pavlov Youri I

Abstract excerpt

Current eukaryotic replication models postulate that leading and lagging DNA strands are replicated predominantly by dedicated DNA polymerases. The catalytic subunit of the leading strand DNA polymerase ε, Pol2, consists of two halves made of two different ancestral B-family DNA polymerases. Counterintuitively, the catalytically active N-terminal half is dispensable, while the inactive C-terminal part is required...

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Share to CDC28 Protein Kinase, S cerevisiae
Share to DNA, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Polymerase II

Share to DNA Replication

Share to Genome, Fungal

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Share to Selection, Genetic

Source

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Identifiers

PMID: 33844024
DOI: 10.1093/genetics/iyab060
PMCID: PMC8225352

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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