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Article

Evidence that DNA polymerase δ contributes to initiating leading strand DNA replication in Saccharomyces cerevisiae.

Nature communications - 27 Feb 2018

Garbacz Marta A, Lujan Scott A, Burkholder Adam B, Cox Phillip B, Wu Qiuqin, Zhou Zhi-Xiong, Haber James E, Kunkel Thomas A

Abstract excerpt

To investigate nuclear DNA replication enzymology in vivo, we have studied Saccharomyces cerevisiae strains containing a pol2-16 mutation that inactivates the catalytic activities of DNA polymerase ε (Pol ε). Although pol2-16 mutants survive, they present very tiny spore colonies, increased doubling time, larger than normal cells, aberrant nuclei, and rapid acquisition of suppressor mutations. These phenotypes...

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Identifiers

PMID: 29487291
DOI: 10.1038/s41467-018-03270-4
PMCID: PMC5829166

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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