Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Balancing act of a leading strand DNA polymerase-specific domain and its exonuclease domain promotes genome-wide sister replication fork symmetry.

Genes & development - 1 Feb 2023

Meng Xiangzhou, Claussin Clémence, Regan-Mochrie Gemma, Whitehouse Iestyn, Zhao Xiaolan

Abstract excerpt

Pol2 is the leading-strand DNA polymerase in budding yeast. Here we describe an antagonism between its conserved POPS (Pol2 family-specific catalytic core peripheral subdomain) and exonuclease domain and the importance of this antagonism in genome replication. We show that multiple defects caused by POPS mutations, including impaired growth and DNA synthesis, genome instability, and reliance on other genome...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Polymerase II
Share to DNA Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exonucleases

Share to Genomic Instability

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 36702483
DOI: 10.1101/gad.350054.122
PMCID: PMC10069448

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Balancing act of a leading strand DNA polymerase-specific domain and its exonuclease domain promotes genome-wide sister replication fork symmetry.PMID 36702483Read ↗

The evolving tale of Pol2 function.Semantic proximity Read ↗

Disease-associated DNA2 nuclease-helicase protects cells from lethal chromosome under-replication.Semantic proximity Read ↗

Alternative RNA degradation pathways by the exonuclease Pop2p from Saccharomyces cerevisiae.Semantic proximity Read ↗

PCNA binding domains in all three subunits of yeast DNA polymerase δ modulate its function in DNA replication.Semantic proximity Read ↗

The DNA polymerase domain of pol(epsilon) is required for rapid, efficient, and highly accurate chromosomal DNA replication, telomere length maintenance, and normal cell senescence in Saccharomyces cerevisiae.Semantic proximity Read ↗

Limiting homologous recombination at stalled replication forks is essential for cell viability: DNA2 to the rescueSemantic proximity Read ↗

Limiting DNA polymerase delta alters replication dynamics and leads to a dependence on checkpoint activation and recombination-mediated DNA repairSemantic proximity Read ↗

Compensation for the absence of the catalytically active half of DNA polymerase ε in yeast by positively selected mutations in CDC28.Semantic proximity Read ↗

Roles of POL3, POL2 and PMS1 genes in maintaining accurate DNA replication.Semantic proximity Read ↗

Deciphering the mechanism of processive ssDNA digestion by the Dna2-RPA ensemble.Semantic proximity Read ↗

Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stress.Semantic proximity Read ↗

The C-terminus of Dpb2 is required for interaction with Pol2 and for cell viability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.