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Article

Hematopoietic stem cell transplantation: Improving alloreactive Bw4 donor selection by genotyping codon 86 of KIR3DL1/S1.

European journal of immunology - 1 Jun 2016

Alicata Claudia, Pende Daniela, Meazza Raffaella, Canevali Paolo, Loiacono Fabrizio, Bertaina Alice, Locatelli Franco, Nemat-Gorgani Neda, Guethlein Lisbeth A, Parham Peter, Moretta Lorenzo, Moretta Alessandro, Bottino Cristina, Norman Paul J, Falco Michela

Abstract excerpt

KIR3DL1 is a natural killer (NK) cell receptor that recognizes the Bw4 epitope of human leukocyte antigen (HLA) class I molecules. Following hematopoietic stem cell transplantation for patients lacking Bw4, KIR3DL1-expressing NK cells from Bw4-positive donors can be alloreactive and eliminate tumor cells. However, KIR3DL1 alleles having T instead of C at nucleotide 320 (encoding leucine 86 instead of serine 86)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26990677
DOI: 10.1002/eji.201546236
PMCID: PMC5065926

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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