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Article

Characterization of Prototheca CYP51/ERG11 as a possible target for therapeutic drugs.

Medical mycology - 3 Sept 2021

Watanabe Takahisa, Ishikawa Tomohiro, Sato Hirotaka, Hirose Noriyuki, Nonaka Lisa, Matsumura Kaori, Masubuchi Akira, Nishimura Kazuko, Masuda Michiaki

Abstract excerpt

Prototheca spp. are achlorophyllous algae, ubiquitous in nature. An increasing number of human and animal cases of Prototheca infection (protothecosis) are reported, and antifungal azoles, which inhibit sterol 14α-demethylase (CYP51/ERG11) involved in ergosterol biosynthesis, have empirically been used for the treatment of protothecosis. Although Prototheca, like fungi, has ergosterol in the cell membrane,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 33838030
DOI: 10.1093/mmy/myab012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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