Article
Contribution of mutations in the cytochrome P450 14alpha-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans.
Microbiology (Reading, England) - 1 Oct 1999
Marichal Patrick, Koymans Luc, Willemsens Staf, Bellens Danny, Verhasselt Peter, Luyten Walter, Borgers Marcel, Ramaekers Frans C S, Odds Frank C, Vanden Bossche Hugo
Abstract excerpt
The cytochrome P450 14alpha-demethylase, encoded by the ERG11 (CYP51) gene, is the primary target for the azole class of antifungals. Changes in the azole affinity of this enzyme caused by amino acid substitutions have been reported as a resistance mechanism. Nine Candida albicans strains were used in this study. The ERG11 base sequence of seven isolates, of which only two were azole-sensitive, were determined....
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