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Article

Cloning and characterization of the lanosterol 14alpha-demethylase (ERG11) gene in Cryptococcus neoformans.

Biochemical and biophysical research communications - 12 Nov 2004

Revankar S G, Fu J, Rinaldi M G, Kelly S L, Kelly D E, Lamb D C, Keller S M, Wickes B L

Abstract excerpt

The ergosterol pathway in fungal pathogens is an attractive antimicrobial target because it is unique from the major sterol (cholesterol) producing pathway in humans. Lanosterol 14alpha-demethylase is the target for a major class of antifungals, the azoles. In this study we have isolated the gene for this enzyme from Cryptococcus neoformans. The gene, ERG11, was recovered using degenerate PCR with primers...

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Source

Identifiers

PMID: 15474487
DOI: 10.1016/j.bbrc.2004.09.112

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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