Article

Synergistic effects of Cyp51 isozyme-specific azole antifungal agents on fungi with multiple cyp51 isozyme genes

2025-04-16

Abstract excerpt

Pathogenic fungi pose significant societal challenges. The limited availability of therapeutic targets due to the eukaryotic nature of fungi emphasizes the importance of available drug targets such as Cyp51, a crucial enzyme in ergosterol biosynthesis, inhibited by azole antifungals. This study explored the susceptibility patterns of azole antifungals against Cyp51 isozyme deletion strains (Δ cyp51A and Δ cyp51B...

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Literature Corpus work: 7d1d10db-bd75-5425-afb6-d4647f879da2
DOI: 10.1101/2025.04.16.649168

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