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Analysis of Cyp51 protein sequences shows 4 major Cyp51 gene family groups across fungi

21 Sept 2022

Abstract excerpt

Azole drugs target fungal sterol biosynthesis and are used to treat millions of human fungal infections each year. Resistance to azole drugs has emerged in multiple fungal pathogens including Candida albicans, Cryptococcus neoformans, Histoplasma capsulatum, and Aspergillus fumigatus. The most well-studied resistance mechanism in A. fumigatus arises from missense mutations in the coding sequence combined with a...

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PMID: 36130263
DOI: 10.1093/g3journal/jkac249

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