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Article

The INO80E at 16p11.2 locus increases risk of schizophrenia in humans and induces schizophrenia-like phenotypes in mice

14 Mar 2025

Abstract excerpt

BACKGROUND: Chromosome 16p11.2 is one of the most significant loci in the genome-wide association studies (GWAS) of schizophrenia. Despite several integrative analyses and functional genomics studies having been carried out to identify possible risk genes, their impacts in the pathogenesis of schizophrenia remain to be fully characterized. METHODS: We performed expression quantitative trait loci (eQTL) and...

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PMID: 40088626
DOI: 10.1016/j.ebiom.2025.105645

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