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Article

Retrieving the deleterious mutations before extinction: genome-wide comparison of shared derived mutations in liver cancer and normal population.

Postgraduate medical journal - 1 Aug 2022

Chang Shuai, Li Jian, Li Qun, Yu Chun-Peng, Xie Ling-Ling, Wang Song

Abstract excerpt

STUDY PURPOSE: Deleterious mutations would be rapidly purged from natural populations along with the extinction of their carriers. The currently observed mutations in existing species are mostly neutral. The inaccessibility of deleterious mutations impedes the functional studies on how these mutations affect the fitness at individual level. STUDY DESIGN: The connection between the deleterious genotype and the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33837126
DOI: 10.1136/postgradmedj-2021-139993

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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