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Article

DNA-mediated coupling of ATPase, translocase and nuclease activities of a Type ISP restriction-modification enzyme.

Nucleic acids research - 18 Mar 2020

Chand Mahesh Kumar, Carle Vanessa, Anuvind K G, Saikrishnan Kayarat

Abstract excerpt

Enzymes involved in nucleic acid transactions often have a helicase-like ATPase coordinating and driving their functional activities, but our understanding of the mechanistic details of their coordination is limited. For example, DNA cleavage by the antiphage defense system Type ISP restriction-modification enzyme requires convergence of two such enzymes that are actively translocating on DNA powered by...

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Identifiers

PMID: 31974580
DOI: 10.1093/nar/gkaa023
PMCID: PMC7049714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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