Article

Modular photostable fluorescent DNA blocks dissect the effects of pathogenic mutant kinesin on collective transport

2024-09-08

Abstract excerpt

<h4>SUMMARY</h4> Intracellular transport is driven by teams of various motor proteins. Advances in DNA nanotechnology have enabled the programmable linkage of different types of motor proteins. In this study, we developed a modular, photostable, fluorescence-labeled tiny DNA origami block (FTOB) for extended observation of collective transport by selected motor combinations. The FTOB is designed as a 4-helix bund...

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Literature Corpus work: ea9b5c39-c442-5aef-a9ee-b94b66fbfde2
DOI: 10.1101/2024.09.06.611758

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