Article
Cotranscriptional R-loop formation by Mfd involves topological partitioning of DNA.
Proceedings of the National Academy of Sciences of the United States of America - 13 Apr 2021
Portman James R, Brouwer Gwendolyn M, Bollins Jack, Savery Nigel J, Strick Terence R
Abstract excerpt
R-loops are nucleic acid hybrids which form when an RNA invades duplex DNA to pair with its template sequence. Although they are implicated in a growing number of gene regulatory processes, their mechanistic origins remain unclear. We here report real-time observations of cotranscriptional R-loop formation at single-molecule resolution and propose a mechanism for their formation. We show that the bacterial Mfd...
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