Article
Comprehensive analysis of germline mutations in northern Brazil: a panel of 16 genes for hereditary cancer-predisposing syndrome investigation.
BMC cancer - 7 Apr 2021
Vidal Amanda Ferreira, Ferraz Rafaella Sousa, El-Husny Antonette, Silva Caio Santos, Vinasco-Sandoval Tatiana, Magalhães Leandro, Raiol-Moraes Milene, Barra Williams Fernandes, Pereira Cynthia Lara Brito Lins, de Assumpção Paulo Pimentel, de Brito Leonardo Miranda, Vialle Ricardo Assunção, Santos Sidney, Ribeiro-Dos-Santos Ândrea, Ribeiro-Dos-Santos André M
Abstract excerpt
BACKGROUND: Next generation sequencing (NGS) has been a handy tool in clinical practice, mainly due to its efficiency and cost-effectiveness. It has been widely used in genetic diagnosis of several inherited diseases, and, in clinical oncology, it may enhance the discovery of new susceptibility genes and enable individualized care of cancer patients. In this context, we explored a pan-cancer panel in the...
Topics
- Brazil
- Female
- Genetic Predisposition to Disease
- Germ-Line Mutation
- High-Throughput Nucleotide Sequencing
- Humans
- Male
- Neoplastic Syndromes, Hereditary