Article
Analysis of hereditary cancer syndromes by using a panel of genes: novel and multiple pathogenic mutations.
BMC cancer - 3 Jun 2019
Tsaousis Georgios N, Papadopoulou Eirini, Apessos Angela, Agiannitopoulos Konstantinos, Pepe Georgia, Kampouri Stavroula, Diamantopoulos Nikolaos, Floros Theofanis, Iosifidou Rodoniki, Katopodi Ourania, Koumarianou Anna, Markopoulos Christos, Papazisis Konstantinos, Venizelos Vasileios, Xanthakis Ioannis, Xepapadakis Grigorios, Banu Eugeniu, Eniu Dan Tudor, Negru Serban, Stanculeanu Dana Lucia, Ungureanu Andrei, Ozmen Vahit, Tansan Sualp, Tekinel Mehmet, Yalcin Suayib, Nasioulas George
Abstract excerpt
BACKGROUND: Hereditary cancer predisposition syndromes are responsible for approximately 5-10% of all diagnosed cancer cases. In the past, single-gene analysis of specific high risk genes was used for the determination of the genetic cause of cancer heritability in certain families. The application of Next Generation Sequencing (NGS) technology has facilitated multigene panel analysis and is widely used in...
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