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Analysis of hereditary cancer syndromes by using a panel of genes: novel and multiple pathogenic mutations

3 Jun 2019

Abstract excerpt

BACKGROUND: Hereditary cancer predisposition syndromes are responsible for approximately 5-10% of all diagnosed cancer cases. In the past, single-gene analysis of specific high risk genes was used for the determination of the genetic cause of cancer heritability in certain families. The application of Next Generation Sequencing (NGS) technology has facilitated multigene panel analysis and is widely used in...

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PMID: 31159747
DOI: 10.1186/s12885-019-5756-4

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