Article
Investigating the prevalence of pathogenic variants in Saudi Arabian patients with familial cancer using a multigene next generation sequencing panel.
Oncotarget - 12 Jun 2023
AlHarbi Musa, Mobark Nahla Ali, AlJabarat Wael Abdel Rahman, ElBardis Hadeel, AlSolme Ebtehal, Hamdan Abdullah Bany, AlFakeeh Ali H, AlMushawah Fatimah, AlHarthi Fawz, AlSharm Abdullah A, Balbaid Ali Abdullah O, AlJohani Naji, Zhou Alicia Y, Robinson Heather A, Alqahtani Saleh A, Abedalthagafi Malak
Abstract excerpt
Family history is an important factor in determining hereditary cancer risk for many cancer types. The emergence of next-generation sequencing (NGS) has expedited the discovery of many hereditary cancer susceptibility genes and the development of rapid, affordable testing kits. Here, a 30-gene targeted NGS panel for hereditary cancer risk assessment was tested and validated in a Saudi Arabian population. A total...
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