SARS-CoV-2 within-host diversity and transmission.

doi:10.1126/science.abg0821

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Article

SARS-CoV-2 within-host diversity and transmission.

Science (New York, N.Y.) - 16 Apr 2021

Lythgoe Katrina A, Hall Matthew, Ferretti Luca, de Cesare Mariateresa, MacIntyre-Cockett George, Trebes Amy, Andersson Monique, Otecko Newton, Wise Emma L, Moore Nathan, Lynch Jessica, Kidd Stephen, Cortes Nicholas, Mori Matilde, Williams Rebecca, Vernet Gabrielle, Justice Anita, Green Angie, Nicholls Samuel M, Ansari M Azim, Abeler-Dörner Lucie, Moore Catrin E, Peto Timothy E A, Eyre David W, Shaw Robert, Simmonds Peter, Buck David, Todd John A, Connor Thomas R, Ashraf Shirin, da Silva Filipe Ana, Shepherd James, Thomson Emma C, Bonsall David, Fraser Christophe, Golubchik Tanya

Abstract excerpt

Extensive global sampling and sequencing of the pandemic virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have enabled researchers to monitor its spread and to identify concerning new variants. Two important determinants of variant spread are how frequently they arise within individuals and how likely they are to be transmitted. To characterize within-host diversity and transmission, we...

Topics

COVID-19
Coinfection
Coronavirus Infections
Coronavirus OC43, Human
Family Characteristics
Genetic Variation
Genome, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Immune Evasion

Mutation

Phylogeny

RNA, Viral

RNA-Seq

SARS-CoV-2

Selection, Genetic

Spike Glycoprotein, Coronavirus

United Kingdom

Viral Load

Source

Open in PubMed Open full text

Identifiers

PMID: 33688063
DOI: 10.1126/science.abg0821
PMCID: PMC8128293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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