Article
Intra-host variation and evolutionary dynamics of SARS-CoV-2 populations in COVID-19 patients.
Genome medicine - 22 Feb 2021
Wang Yanqun, Wang Daxi, Zhang Lu, Sun Wanying, Zhang Zhaoyong, Chen Weijun, Zhu Airu, Huang Yongbo, Xiao Fei, Yao Jinxiu, Gan Mian, Li Fang, Luo Ling, Huang Xiaofang, Zhang Yanjun, Wong Sook-San, Cheng Xinyi, Ji Jingkai, Ou Zhihua, Xiao Minfeng, Li Min, Li Jiandong, Ren Peidi, Deng Ziqing, Zhong Huanzi, Xu Xun, Song Tie, Mok Chris Ka Pun, Peiris Malik, Zhong Nanshan, Zhao Jingxian, Li Yimin, Li Junhua, Zhao Jincun
Abstract excerpt
BACKGROUND: Since early February 2021, the causative agent of COVID-19, SARS-CoV-2, has infected over 104 million people with more than 2 million deaths according to official reports. The key to understanding the biology and virus-host interactions of SARS-CoV-2 requires the knowledge of mutation and evolution of this virus at both inter- and intra-host levels. However, despite quite a few polymorphic sites...
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