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Article

The interaction of child abuse and rs1360780 of the FKBP5 gene is associated with amygdala resting-state functional connectivity in young adults.

Human brain mapping - 1 Jul 2021

Wesarg Christiane, Veer Ilya M, Oei Nicole Y L, Daedelow Laura S, Lett Tristram A, Banaschewski Tobias, Barker Gareth J, Bokde Arun L W, Quinlan Erin Burke, Desrivières Sylvane, Flor Herta, Grigis Antoine, Garavan Hugh, Brühl Rüdiger, Martinot Jean-Luc, Artiges Eric, Nees Frauke, Orfanos Dimitri Papadopoulos, Poustka Luise, Hohmann Sarah, Fröhner Juliane H, Smolka Michael N, Whelan Robert, Schumann Gunter, Heinz Andreas, Walter Henrik

Abstract excerpt

Extensive research has demonstrated that rs1360780, a common single nucleotide polymorphism within the FKBP5 gene, interacts with early-life stress in predicting psychopathology. Previous results suggest that carriers of the TT genotype of rs1360780 who were exposed to child abuse show differences in structure and functional activation of emotion-processing brain areas belonging to the salience network. Extending...

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PMID: 33818852
DOI: 10.1002/hbm.25433
PMCID: PMC8193540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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