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Article

Role of FKBP5 in emotion processing: results on amygdala activity, connectivity and volume.

Brain structure & function - 1 Jan 2015

Holz Nathalie E, Buchmann Arlette F, Boecker Regina, Blomeyer Dorothea, Baumeister Sarah, Wolf Isabella, Rietschel Marcella, Witt Stephanie H, Plichta Michael M, Meyer-Lindenberg Andreas, Banaschewski Tobias, Brandeis Daniel, Laucht Manfred

Abstract excerpt

Accumulating evidence suggests a role of FKBP5, a co-chaperone regulating the glucocorticoid receptor sensitivity, in the etiology of depression and anxiety disorders. Based on recent findings of altered amygdala activity following childhood adversity, the present study aimed at clarifying the impact of genetic variation in FKBP5 on threat-related neural activity and coupling as well as morphometric alterations...

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Source

Identifiers

PMID: 24756342
DOI: 10.1007/s00429-014-0729-5

Genes

FKBP5

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Click a neighbor to travelStep 1 · 12 closest

Role of FKBP5 in emotion processing: results on amygdala activity, connectivity and volume.PMID 24756342Read ↗

Epigenetic Changes of FKBP5 as a Link Connecting Genetic and Environmental Risk Factors with Structural and Functional Brain Changes in Major Depression.Semantic proximity Read ↗

Single-Nucleotide Polymorphism of the FKBP5 Gene and Childhood Maltreatment as Predictors of Structural Changes in Brain Areas Involved in Emotional Processing in Depression.Semantic proximity Read ↗

The rs1360780 Variant of FKBP5: Genetic Variation, Epigenetic Regulation, and Behavioral PhenotypesSemantic proximity Read ↗

FKBP5 and emotional neglect interact to predict individual differences in amygdala reactivity.Semantic proximity Read ↗

FKBP5 and attention bias for threat: associations with hippocampal function and shape.Semantic proximity Read ↗

FKBP5 intron 7 methylation is associated with higher anxiety proneness and smaller right thalamus volume in adolescents.Semantic proximity Read ↗

Hypothalamic-pituitary-adrenal axis genetic variation and early stress moderates amygdala function.Semantic proximity Read ↗

Moderating role of FKBP5 genotype in the impact of childhood adversity on cortisol stress response during adulthood.Semantic proximity Read ↗

Psychiatric symptoms in adolescents: FKBP5 genotype--early life adversity interaction effects.Semantic proximity Read ↗

FKBP5 is associated with amygdala volume in the human brain and mood state: A voxel-based morphometry (VBM) study.Semantic proximity Read ↗

The interaction of child abuse and rs1360780 of the FKBP5 gene is associated with amygdala resting-state functional connectivity in young adults.Semantic proximity Read ↗

Early-Life Adversity Interacts with FKBP5 Genotypes: Altered Working Memory and Cardiac Stress Reactivity in the Oklahoma Family Health Patterns Project.Semantic proximity Read ↗

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