Effect of interaction between a specific subtype of child abuse and the FKBP5 rs1360780 SNP on DNA methylation among patients with bipolar disorder.

doi:10.1016/j.jad.2020.03.120

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Article

Effect of interaction between a specific subtype of child abuse and the FKBP5 rs1360780 SNP on DNA methylation among patients with bipolar disorder.

Journal of affective disorders - 1 Jul 2020

Saito Taku, Shinozaki Gen, Koga Minori, Tanichi Masaaki, Takeshita Shogo, Nakagawa Ryuichi, Nagamine Masanori, Cho Hyunkeun R, Morimoto Yuji, Kobayashi Yasushi, Yoshino Aihide, Toda Hiroyuki

Abstract excerpt

BACKGROUND: Child abuse is a risk factor for mood disorders, and linked to decreased DNA methylation (DNAm) of FKBP5 intron 7 through interactions with the single nucleotide polymorphism (SNP) rs1360780. However, no study has investigated which specific subtypes of child abuse are related to decreased DNAm of FKBP5 intron 7 in mood disorders. We therefore aimed to examine the relationship among various subtypes...

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PMID: 32553385
DOI: 10.1016/j.jad.2020.03.120

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