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Article

Reduced functional connectivity of fronto-parietal sustained attention networks in severe childhood abuse.

PloS one - 1 Jan 2017

Hart Heledd, Lim Lena, Mehta Mitul A, Chatzieffraimidou Antonia, Curtis Charles, Xu Xiaohui, Breen Gerome, Simmons Andrew, Mirza Kah, Rubia Katya

Abstract excerpt

Childhood maltreatment is associated with attention deficits. We examined the effect of childhood abuse and abuse-by-gene (5-HTTLPR, MAOA, FKBP5) interaction on functional brain connectivity during sustained attention in medication/drug-free adolescents. Functional connectivity was compared, using generalised psychophysiological interaction (gPPI) analysis of functional magnetic resonance imaging (fMRI) data,...

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Source

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Identifiers

PMID: 29190830
DOI: 10.1371/journal.pone.0188744
PMCID: PMC5708742

Genes

FKBP5
MAOA

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