Moderation of adult depression by a polymorphism in the FKBP5 gene and childhood physical abuse in the general population.

doi:10.1038/npp.2011.81

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Article

Moderation of adult depression by a polymorphism in the FKBP5 gene and childhood physical abuse in the general population.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Sept 2011

Appel Katja, Schwahn Christian, Mahler Jessie, Schulz Andrea, Spitzer Carsten, Fenske Kristin, Stender Jan, Barnow Sven, John Ulrich, Teumer Alexander, Biffar Reiner, Nauck Matthias, Völzke Henry, Freyberger Harald J, Grabe Hans J

Abstract excerpt

Childhood maltreatment and depressive disorders have both been associated with a dysregulation of the hypothalamic-pituitary-adrenal axis. The FKBP5 gene codes for a co-chaperone regulating the glucocorticoid-receptor sensitivity. Previous evidence suggests that subjects carrying the TT genotype of the FKBP5 gene single-nucleotide polymorphism (SNP) rs1360780 have an increased susceptibility to adverse effects of...

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PMID: 21654733
DOI: 10.1038/npp.2011.81
PMCID: PMC3158316

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FKBP5

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