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Interactions of COMT and ALDH2 Genetic Polymorphisms on Symptoms of Parkinson’s Disease

12 Mar 2021

Abstract excerpt

(1) Background: Monoamine neurotransmitters play essential roles in the normal functioning of our nervous system. However, the metabolism of monoamine neurotransmitters is accompanied by the production of neurotoxic metabolites, and inefficient removal of the metabolites has been suggested to cause neurodegeneration. (2) Methods: To examine the effect of reduced activity of catechol-O-methyltransferase (COMT) and...

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PMID: 33808974
DOI: 10.3390/brainsci11030361

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