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Article

Effect of ALDH2 on Sleep Disturbances in Patients with Parkinson's Disease.

Scientific reports - 12 Dec 2019

Lin Chia-Yen, Yu Rwei-Ling, Wu Ruey-Meei, Tan Chun-Hsiang

Abstract excerpt

Monoamine neurotransmitters play essential roles in the regulation of arousal and sleep. Impaired metabolism of monoamine neurotransmitters could result in the accumulation of neurotoxic aldehyde metabolites and, hence, neuronal degeneration. Aldehyde dehydrogenases play an important role in the metabolism of the neurotoxic aldehyde metabolites, including the aldehyde metabolites of dopamine, serotonin, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31831791
DOI: 10.1038/s41598-019-55427-w
PMCID: PMC6908732

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