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Article

Polymorphisms of Catechol-O-Methyl Transferase (COMT) Gene in Vulnerability to Levodopa-Induced Dyskinesia.

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques - 1 Jan 2018

Ivanova Svetlana A, Alifirova Valentina M, Pozhidaev Ivan V, Freidin Maxim B, Zhukova Irina A, Osmanova Diana Z, Zhukova Natalia G, Mironova Yulia A, Tiguntsev Vladimir V, Fedorenko Olga Yu, Bokhan Nikolay A, Wilffert Bob, Loonen Anton J M

Abstract excerpt

PURPOSE: Parkinson's disease (PD), a common neurodegenerative disorder, is usually treated with Levodopa (L-DOPA). The use of this drug, however, is severely limited by the development of side effects of the motor system: Levodopa-induced dyskinesia (LID). The aim of this study is to investigate the association between seven COMT gene single-nucleotide polymorphisms (SNPs) and the development of LID in patients...

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Source

Identifiers

PMID: 30075828
DOI: 10.18433/jpps29903

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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