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Article

The association of functional catechol-O-methyltransferase haplotypes with risk of Parkinson's disease, levodopa treatment response, and complications

12 Aug 2008

Abstract excerpt

INTRODUCTION: Differences in catechol-O-methyltransferase (COMT) activity and genotype may determine individual variations in the therapeutic response to levodopa or Parkinson's disease (PD) susceptibility. The role of functional COMT haplotypes in PD susceptibility and treatment response has not been examined. OBJECTIVES: In this case-control study, we investigated the association of the most common COMT gene...

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PMID: 18698234
DOI: 10.1097/fpc.0b013e328306c2f2

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