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Article

Association of Catechol-O-Methyltransferase and monoamine oxidase B gene polymorphisms with motor complications in parkinson's disease in a Chinese population.

Parkinsonism & related disorders - 1 Oct 2014

Hao Hongying, Shao Ming, An Jing, Chen Chushuang, Feng Xiuli, Xie Shu, Gu Zhuqin, Chan Piu

Abstract excerpt

BACKGROUND: Catechol-O-Methyltransferase (COMT) and Monoamine oxidase B (MAO-B) are the main enzymes that metabolize dopamine in the brain. The polymorphisms of the COMT gene and MAO-B gene are associated with high, intermediate and low levels of activity. This may influence the prevalence of motor complications in Parkinson's Disease (PD). METHODS: The study enrolled 1087 Chinese PD patients throughout the...

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Source

Identifiers

PMID: 25034874
DOI: 10.1016/j.parkreldis.2014.06.021

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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