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Article

Association of Catechol-O-Methyltransferase Gene rs4680 Polymorphism and Levodopa Induced Dyskinesia in Parkinson's Disease: A Meta-Analysis and Systematic Review.

Journal of geriatric psychiatry and neurology - 1 Mar 2023

Dwivedi Archana, Dwivedi Nidhi, Kumar Anand, Singh Varun K, Pathak Abhishek, Chaurasia R N, Mishra V N, Mohanty Sujata, Joshi Deepika

Abstract excerpt

INTRODUCTION: Long-term levodopa therapy for Parkinson's disease (PD) can cause levodopa induced dyskinesia (LID). Genetic predisposition has a significant role to play in inter-individual heterogeneity in the clinical manifestation of LID. Despite accumulating evidence for the role of COMT gene polymorphism (rs4680) as a genetic basis for LID, to date results have been inconsistent. Early assessment of the...

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PMID: 35603896
DOI: 10.1177/08919887221103580

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