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Article

Genetic variations in catechol-O-methyltransferase gene are associated with levodopa response variability in Chinese patients with Parkinson's disease.

Scientific reports - 12 Jun 2020

Zhao Cuiping, Wang Yihua, Zhang Bin, Yue Yaoxian, Zhang Jianyuan

Abstract excerpt

Catechol-O-methyltransferase (COMT) is one of the main enzymes in dopamine metabolism and is reported to be associated with susceptibility to Parkinson's disease (PD) and pharmacotherapy. However, researchers mostly focus on the most common polymorphism, rs4680. In this case-control study, we investigated the association of SNPs other than rs4680 with the levodopa (L-dopa) response and other clinical features in...

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Identifiers

PMID: 32533012
DOI: 10.1038/s41598-020-65332-2
PMCID: PMC7293305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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