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Article

Genetic polymorphisms involved in dopaminergic neurotransmission and risk for Parkinson's disease in a Japanese population.

BMC neurology - 25 Jul 2011

Kiyohara Chikako, Miyake Yoshihiro, Koyanagi Midori, Fujimoto Takahiro, Shirasawa Senji, Tanaka Keiko, Fukushima Wakaba, Sasaki Satoshi, Tsuboi Yoshio, Yamada Tatsuo, Oeda Tomoko, Shimada Hiroyuki, Kawamura Nobutoshi, Sakae Nobutaka, Fukuyama Hidenao, Hirota Yoshio, Nagai Masaki

Abstract excerpt

BACKGROUND: Parkinson's disease (PD) is characterized by alterations in dopaminergic neurotransmission. Genetic polymorphisms involved in dopaminergic neurotransmission may influence susceptibility to PD. METHODS: We investigated the relationship of catechol-O-methyltransferase (COMT), monoamine oxidase B (MAOB), dopamine receptor (DR) D2 and DRD4 polymorphisms and PD risk with special attention to the...

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Identifiers

PMID: 21781348
DOI: 10.1186/1471-2377-11-89
PMCID: PMC3199768

Genes

COMT
MAOB
DRD4
DRD2

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