Article
Fetal Microsatellite in the Heme Oxygenase 1 Promoter Is Associated With Severe and Early-Onset Preeclampsia.
Hypertension (Dallas, Tex. : 1979) - 1 Jan 2018
Kaartokallio Tea, Utge Siddheshwar, Klemetti Miira M, Paananen Jussi, Pulkki Kari, Romppanen Jarkko, Tikkanen Ilkka, Heinonen Seppo, Kajantie Eero, Kere Juha, Kivinen Katja, Pouta Anneli, Lakkisto Päivi, Laivuori Hannele
Abstract excerpt
Preeclampsia is a vascular pregnancy disorder that often involves impaired placental development. HO-1 (heme oxygenase 1, encoded by HMOX1) is a stress response enzyme crucial for endothelial and placental function. Long version of the guanine-thymine (GTn) microsatellite in the HMOX1 promoter decreases HO-1 expression, and the long maternal repeat is associated with late-onset preeclampsia. Our aim was to study...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.