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Article

Role of heme oxygenase-1 in human endothelial cells: lesson from the promoter allelic variants.

Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2010

Taha Hevidar, Skrzypek Klaudia, Guevara Ibeth, Nigisch Anneliese, Mustafa Stefan, Grochot-Przeczek Anna, Ferdek Pawel, Was Halina, Kotlinowski Jerzy, Kozakowska Magdalena, Balcerczyk Aneta, Muchova Lucie, Vitek Libor, Weigel Guenter, Dulak Jozef, Jozkowicz Alicja

Abstract excerpt

OBJECTIVE: Heme oxygenase-1 (HO-1) is an antioxidative, antiinflammatory, and cytoprotective enzyme that is induced in response to cellular stress. The HO-1 promoter contains a (GT)n microsatellite DNA, and the number of GT repeats can influence the occurrence of cardiovascular diseases. We elucidated the effect of this polymorphism on endothelial cells isolated from newborns of different genotypes. METHODS AND...

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Identifiers

PMID: 20508205
DOI: 10.1161/ATVBAHA.110.207316
PMCID: PMC2906705

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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