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Article

Heme oxygenase-1 promoter polymorphisms and risk of spina bifida.

Birth defects research. Part A, Clinical and molecular teratology - 1 Sept 2015

Fujioka Kazumichi, Yang Wei, Wallenstein Matthew B, Zhao Hui, Wong Ronald J, Stevenson David K, Shaw Gary M

Abstract excerpt

BACKGROUND: Spina bifida is the most common form of neural tube defects (NTDs). Etiologies of NTDs are multifactorial, and oxidative stress is believed to play a key role in NTD development. Heme oxygenase (HO), the rate-limiting enzyme in heme degradation, has multiple protective properties including mediating antioxidant processes, making it an ideal candidate for study. The inducible HO isoform (HO-1) has two...

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Identifiers

PMID: 26173399
DOI: 10.1002/bdra.23343
PMCID: PMC6532789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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