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Article

HMOX1 Genetic Polymorphisms Display Ancestral Diversity and May Be Linked to Hypertensive Disorders in Pregnancy.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Dec 2022

Sun Tianyanxin, Cruz Giovanna I, Mousavi Nima, Marić Ivana, Brewer Alina, Wong Ronald J, Aghaeepour Nima, Sayed Nazish, Wu Joseph C, Stevenson David K, Leonard Stephanie A, Gymrek Melissa, Winn Virginia D

Abstract excerpt

Racial disparity exists for hypertensive disorders in pregnancy (HDP), which leads to disparate morbidity and mortality worldwide. The enzyme heme oxygenase-1 (HO-1) is encoded by HMOX1, which has genetic polymorphisms in its regulatory region that impact its expression and activity and have been associated with various diseases. However, studies of these genetic variants in HDP have been limited. The objective...

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Identifiers

PMID: 35697922
DOI: 10.1007/s43032-022-01001-1
PMCID: PMC9734242

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