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Article

Host genetic control of natural killer cell diversity revealed in the Collaborative Cross.

Proceedings of the National Academy of Sciences of the United States of America - 9 Mar 2021

Dupont Magali S J, Guillemot Vincent, Campagne Pascal, Serafini Nicolas, Marie Solenne, Montagutelli Xavier, Di Santo James P, Vosshenrich Christian A J

Abstract excerpt

Natural killer (NK) cells are innate effectors armed with cytotoxic and cytokine-secreting capacities whose spontaneous antitumor activity is key to numerous immunotherapeutic strategies. However, current mouse models fail to mirror the extensive immune system variation that exists in the human population which may impact on NK cell-based therapies. We performed a comprehensive profiling of NK cells in the...

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Share to Antigens, Ly
Share to Crosses, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Killer Cells, Natural

Share to Mice, Inbred Strains

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Source

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Identifiers

PMID: 33649222
DOI: 10.1073/pnas.2018834118
PMCID: PMC7958182

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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