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Article

Suppression of LKB1-mutant lung adenocarcinoma by natural killer cells from females.

Journal of the National Cancer Institute - 1 Sept 2025

Fan Yijian, Jin Rui, Monterroza Lenore, Liu Xiuju, Huang Chunzi, Marra Angelo, Mo Xiulei, Fu Haian, Gilbert-Ross Melissa, Marcus Adam I, Tirouvanziam Rabindra, Liu Yuan, Schneider Frank, Zhou Wei

Abstract excerpt

BACKGROUND: This study addressed the enigma of sex differences in smoking-related lung cancer, particularly focusing on the low LKB1 mutation frequency in female patients with lung adenocarcinoma. METHODS: Sex bias was studied with a genetically engineered mouse model and various tail-vein injection models. Immune cells were analyzed by antibody-depletion study, flow cytometry, and immunofluorescence. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40511603
DOI: 10.1093/jnci/djaf138
PMCID: PMC12415955

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