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Article

Association study of the β-arrestin 2 gene (ARRB2) with opioid and cocaine dependence in a European-American population.

Psychiatric genetics - 1 Jun 2012

Ambrose-Lanci Lisa M, Vaswani Meera, Clarke Toni-Kim, Zeng Angela, Lohoff Falk W, Ferraro Thomas N, Berrettini Wade H

Abstract excerpt

The rewarding properties of drugs of abuse are mediated by the mu-opioid receptor (MOR). Genetic variations in MOR and MOR interacting proteins (MORIPs) involved in MOR signaling may increase the risk for drug dependence. The MORIP β-arrestin plays an important role in the regulation of MOR trafficking, thereby highlighting it as a candidate gene for addiction phenotypes. In this case-control association study,...

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Source

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Identifiers

PMID: 22472784
DOI: 10.1097/YPG.0b013e3283539528
PMCID: PMC3920286

Genes

ARRB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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