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Article

The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence.

Biological psychiatry - 1 Jan 2010

Enoch Mary-Anne, Hodgkinson Colin A, Yuan Qiaoping, Shen Pei-Hong, Goldman David, Roy Alec

Abstract excerpt

BACKGROUND: The GABRA2 gene has been implicated in addiction. Early life stress has been shown to alter GABRA2 expression in adult rodents. We hypothesized that childhood trauma, GABRA2 variation, and their interaction would influence addiction vulnerability. METHODS: African-American men were recruited for this study: 577 patients with lifetime DSM-IV single and comorbid diagnoses of alcohol, cocaine, and heroin...

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Source

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Identifiers

PMID: 19833324
DOI: 10.1016/j.biopsych.2009.08.019
PMCID: PMC2964936

Genes

GABRA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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