Article
β-Arrestin2 influences the response to methadone in opioid-dependent patients.
The pharmacogenomics journal - 1 Aug 2011
Oneda B, Crettol S, Bochud M, Besson J, Croquette-Krokar M, Hämmig R, Monnat M, Preisig M, Eap C B
Abstract excerpt
β-Arrestin2 (ARRB2) is a component of the G-protein-coupled receptor complex and is involved in μ-opioid and dopamine D(2) receptor signaling, two central processes in methadone signal transduction. We analyzed 238 patients in methadone maintenance treatment (MMT) and identified a haplotype block (rs34230287, rs3786047, rs1045280 and rs2036657) spanning almost the entire ARRB2 locus. Although none of these single...
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