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Article

Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model

27 Jul 2020

Abstract excerpt

Abstract Reactive astrocytes have been implicated in the pathogenesis of neurodegenerative diseases, including a non-cell autonomous effect on motor neuron survival in ALS. We previously defined a mechanism by which microglia release three factors, IL-1α, TNFα, and C1q, to induce neurotoxic astrocytes. Here we report that knocking out these three factors markedly extends survival in the SOD1 G93A ALS mouse model,...

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PMID: 32719333
DOI: 10.1038/s41467-020-17514-9

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