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Article

RNA demethylation by FTO stabilizes the FOXJ1 mRNA for proper motile ciliogenesis.

Developmental cell - 19 Apr 2021

Kim Hyunjoon, Lee Young-Suk, Kim Seok-Min, Jang Soohyun, Choi Hyunji, Lee Jae-Won, Kim Tae-Don, Kim V Narry

Abstract excerpt

Adenosine N6-methylation (m6A) is one of the most pervasive mRNA modifications, and yet the physiological significance of m6A removal (demethylation) remains elusive. Here, we report that the m6A demethylase FTO functions as a conserved regulator of motile ciliogenesis. Mechanistically, FTO demethylates and thereby stabilizes the mRNA that encodes the master ciliary transcription factor FOXJ1. Depletion of Fto in...

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PMID: 33761320
DOI: 10.1016/j.devcel.2021.03.006

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